Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-
BMS-265246
CAS: 582315-72-8
Molecular Formula: C18H17F2N3O2
Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)- - Names and Identifiers
Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)- - Physico-chemical Properties
| Molecular Formula | C18H17F2N3O2 |
| Molar Mass | 345.34 |
| Density | 1.304±0.06 g/cm3(Predicted) |
| Boling Point | 552.9±50.0 °C(Predicted) |
| pKa | 8.50±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | BMS265246 inhibited CDK4/cycD activity with an IC50 of 0.23 μm and inhibited A2780 Cytox with an IC50 of 0.76 μm. BMS265246 binds to CDK2, the inhibitory site coincides with the ATP purine binding site, and forms important hydrogen bonds with Leu83 on the protein backbone. BMS265246 potently inhibits CDK1 and cdk2. BMS265246 represents the most potent CDK/CDK2 selective analog. BMS265246 inhibited CDK4/cycD activity with an IC50 of 0.23 μm and inhibited A2780 Cytox with an IC50 of 0.76 μm. BMS265246 binds to CDK2, the inhibitory site coincides with the ATP purine binding site, and forms important hydrogen bonds with Leu83 on the protein backbone. BMS265246 potently inhibits CDK1 and cdk2. BMS265246 represents the most potent CDK/CDK2 selective analog. |
Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.896 ml | 14.478 ml | 28.957 ml |
| 5 mM | 0.579 ml | 2.896 ml | 5.791 ml |
| 10 mM | 0.29 ml | 1.448 ml | 2.896 ml |
| 5 mM | 0.058 ml | 0.29 ml | 0.579 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: BMS-265246 Visit Supplier Webpage Request for quotationCAS: 582315-72-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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